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KMID : 0617219960070010089
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Duksung Bulletin Phamaceutical Sciences
1996 Volume.7 No. 1 p.89 ~ p.101
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The Effects of Smilacis chinae Rhizoma extracts on acetaminophen-induced hepatotoxicity
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Abstract
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The present study was designed to examine the antihepatotoxic effect of Smilacis chinae Rhizoma extract. The ratio of liver to body weight, changes in serum enzyme activities, serum cholesterol, total lipid, bilirubin and urea nitrogen were measured in the rats treated with Smilacis chinae Rhizoma extract(p.o.) followed by the administration of acetaminophen(1800㎎/㎏, p.o.). The ratio of liver to body weight in the rats treated with AAP was 30% greater than that in untreated rats. Treatment of rats with both Smilacis chinae Rhizoma extract and AAP caused decreases in the ratio as compared with the rats treated with AAP : 75.64% by methanol extract, 48.72% by haxane fraction, 78.21% by ether fraction, 58.35% by ethyl acetate fraction, 66.67% by butanol fraction and 85.90% by aqueous fraction. Treatment of rats with both AAP and Smilacis chinae Rhizoma extract resulted in decreases in serum enzyme activities of AST, ALT, ALP and serum cholesterol, total lipid, bilirubin, urea nitrogen contents relative to the rats treated with AAP alone. 30∼78 % decreases in AST and ALT activities were observed in the rats treated with both AAP and Smilacis chinae Rhizoma extract as compared with those from AAP-treated rats. Treatment of rats with Smilacis chinae Rhizoma extract caused decreases in AAP-induced elevation of total cholesterol, total lipid, total bilirubin and urea nitrogen contents which are induced by AAP, 20∼83%, respectively. These results showed that Smilacis chinae Rhizoma extract contains the components which are active against AAP-induced liver damage.
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